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VMFS vs RDM

VMFS

1. Volume can host many virtual machines (or can be dedicated to one virtual machine).
2. Increases storage utilization, provides better flexibility, easier administration and management.
3. Large third-party ecosystem with V2P products to aid in certain support situations.
4. Does not support quorum disks required for third-party clustering software.
5. Fully supports VMware vCenter™ Site Recovery Manager (SRM).

RDM

1. Maps a single LUN to one virtual machine so only one virtual machine is possible per LUN.
2. More LUNs are required, so it is easier to reach the LUN limit of 256 that can be presented to an ESX host.
3. Uses RDM to leverage array-level backup and replication tools integrated with SQL Server databases.
4. RDM volumes can help facilitate migrating physical SQL Server instances to virtual machines.
5. Required for third-party clustering software (e.g., MSCS). Cluster data and quorum disks should be configured with RDM.
6. Some customers use RDMs for SQL Server databases and logs to guarantee that no other VMs are provisioned to those LUNs.
7. Fully supports VMware vCenter Site Recovery Manager.
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