Multiple
VPN channels are required to communicate to multiple VPCs even within single region in AWS whereas a single AWS Direct connect can be connected to multiple VPCs within a single region.
Multiple
VPN channels are required for multiple AWS accounts in a single region whereas a single AWS Direct connect can be connected to multiple AWS accounts within a single region.
You can get lower network latency in AWS Direct connect that in VPN.
AWS direct connect is a dedicated line provisioning which handles the subnet traffic from your on prem site and then in to your VPC. VPN would be a good backup solution in case your ISP had an outage.
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